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KMID : 1134820130420071029
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Journal of the Korean Society of Food Science and Nutrition
2013 Volume.42 No. 7 p.1029 ~ p.1035
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Inhibitory Effects of Phellinus linteus and Rice with Phellinus linteus Mycelium on Obesity and Diabetes
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Kim Hae-Seop
You Je-Heon
Cho Young-Chul
Lee Young-Jae
Park In-Bae
Park Jeong-Wook
Jung Myung-A
Kim Young-Suk
Kim Sun-Oh
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Abstract
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The objective of this study was to examine the ability of extracts from Phellinus linteus (PL) and rice with Phellinus linteus mycelium (PLM) to inhibit obesity and diabetes. The efficacy of PL and PLM were evaluated using Oil Red O staining, cholesteryl ester transfer protein (CETP) levels, protein tyrosine phosphate 1B (PTP1B) levels, organ weight, and serum lipid levels. Lipid accumulation significantly decreased by 76% and 59% upon treatment with 300 μg/mL of PL and PLM, respectively (P<0.01). The inhibition of CETP activity increased 99% upon treatment with 300 μg/mL of PL or PLM. Treatment with 3, 10, 30, 100, and 300 μg/mL of PL, changed PTP1B activity by 10, 11, 14, 12, and 18% respectively. Also, treatment with increasing concentrations of PLM led to a significant concentration-dependent inhibition of PTP1B activity (P<0.01). PL and PLM were orally administered for 28 days after a high fat diet (HFD). PL significantly (P<0.05) reduced triglyceride and cholesterol levels. In addition, PLM significantly (P<0.05) reduced triglyceride, cholesterol, and HDL-cholesterol levels. GOT and GPT were not significantly affected. These results indicate that PL and PLM extracts have potent and useful activities for the treatment of obesity and diabetes mellitus.
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KEYWORD
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3T3-L1 adipocyte, PTP1B, CETP, lipid accumulation, cholesterol
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